2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19818
    NAN-190 102392-05-2 98%
    NAN-190 is a serotonin receptor 5-HT antagonist.
    NAN-190
  • HY-19841
    AVE-5997 452917-21-4 98%
    AVE-5997 is a selective b>D3 antagonist. AVE-5997 antagonizes MK-801 (HY-15084B)-induced hyperactivity. AVE-5997 can be used in the research of schizophrenia.
    AVE-5997
  • HY-19845
    Ordopidine 871351-60-9 98%
    Ordopidine is a dopamine D2 receptor antagonist. Ordopidine can inhibit hyperactivity caused by psychostimulants. Ordopidine can be used in neurological research.
    Ordopidine
  • HY-19858
    LY-466195 317844-33-0 98%
    LY-466195 is a selective and competitive GLUK5 receptor antagonist. LY-466195 antagonizes Kainate-induced currents with an IC50 value of 0.045 μM in rat dorsal root ganglion neurons. In HEK293 cells transfected with GLUK5, GLUK2/GLUK5, or GLUK5/GLUK66 receptors, LY466195 produces IC50 values of 0.08 μM, 0.34 μM, and 0.07 μM, respectively.
    LY-466195
  • HY-19875
    Seridopidine 883631-51-4 98%
    Seridopidine is an orally active dopamine-like compound. Seridopidine can be used in research related to the nervous system.
    Seridopidine
  • HY-19881
    ABT-288 948845-91-8 98%
    ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. ABT-288 has Ki values of 1.9 and 8.2 nM for human and rat H3Rs, respectively. ABT-288 can be used in cognitive impairment research..
    ABT-288
  • HY-19887
    Tilapertin 1000690-85-6 98%
    Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).
    Tilapertin
  • HY-19902
    GSK1521498 1426543-84-1 98%
    GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents.
    GSK1521498
  • HY-21994
    Org-12962 hydrochloride 210821-63-9 98%
    Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.
    Org-12962 hydrochloride
  • HY-21995
    BGC20-761 17375-63-2 98%
    BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent.
    BGC20-761
  • HY-30647
    RS-86 3576-73-6 98%
    RS-86 is a potent, central acting, and selective muscarinic acetylcholine receptor agonist. RS-86 exhibits typical cholinergic excitatory effects, such as inducing smooth muscle contraction, ganglion depolarization, central hypothermia, etc. RS-86 can be used for research on Alzheimer's disease.
    RS-86
  • HY-33879
    Brofoxine 21440-97-1 98.45%
    Brofoxine is a progesterone receptor modulator with anti-anxiety properties.
    Brofoxine
  • HY-41240
    (R)-3-Aminoazepan-2-one 28957-33-7 98%
    (R)-3-Aminoazepan-2-one (compound 9B) is a synthetic intermediate useful for pharmaceutical synthesis.
    (R)-3-Aminoazepan-2-one
  • HY-42849
    Sultopride 53583-79-2 98%
    Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.
    Sultopride
  • HY-43711
    Nor-benzetimide 19315-71-0 98%
    Nor-benzetimide is a major metabolite of Benzetimide. Benzetimide is a mAChR antagonist with anticholinergic activity.
    Nor-benzetimide
  • HY-44132
    Dehydro Palonosetron 135729-56-5 98%
    Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors.
    Dehydro Palonosetron
  • HY-44602
    Thioaspirine 55819-78-8 98%
    Thioaspirine is a carbonic anhydrase (CA) inhibitor with Kis of 64.3 and 10.9 μM for hCA II and hCA IX, respectively. Thioaspirine effectively relieves the inflammatory pain in CFA (HY-153808)-treated mice. Thioaspirine can be used for inflammatory pain research.
    Thioaspirine
  • HY-45588
    Geranylamine 6246-48-6 98%
    Geranylamine is an acyclic monoterpene amine that serves as a drug intermediate for the synthesis of a series of TRP channel modulators and antibacterial agents.
    Geranylamine
  • HY-46286
    TTFB 352560-76-0 99.83%
    TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel (ZAC) antagonist. TTFB inhibits Zn2+- and H+-induced ZAC currents with IC50 values of 3 μM and 8.5 μM, respectively, and has an IC50 of 4.7 μM against spontaneous activity. TTFB shows no significant agonistic, antagonistic or modulatory activity towards representative classical Cys-loop receptors including m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR and hα1 GlyR. TTFB can be used to investigate the physiological and pathological functions of ZAC.
    TTFB
  • HY-48869
    PI3K-IN-46 304645-61-2 98.0%
    PI3K-IN-46 (Intermediate 4) is an intermediate in the synthesis of PI3K inhibitor (2-imino-azolinone-vinyl fused-benzene derivative) that can be used for the research of autoimmune disorders, cardiovascular diseases, and neurodegenerative diseases.
    PI3K-IN-46
Cat. No. Product Name / Synonyms Application Reactivity